home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Holding Off HIV

 
  September, 17 2009 9:26
your information resource in human molecular genetics
 
     

Scientists have discovered a new strategy to inhibit HIV entry into host cells, as published online in Nature Chemical Biology.

HIV normally enters cells when gp120, a protein on the surface of HIV, binds to receptors on the host cell. In this process, gp120 first binds to one receptor -- CD4 -- which causes the structure of the protein to change so that it can bind to a second receptor, such as CCR5 or heparan sulfate.

Hugues Lortat-Jacob and colleagues have now made a molecule that contains a sequence of amino acids to mimic CD4 and a sequence of carbohydrates to mimic heparan sulfate to bind to both sites on gp120. This new strategy results in very effective inhibition of HIV infection in cellular assays, and so may have implications for further antiviral efforts.

Author contact:

Hugues Lortat-Jacob (CNRS, Grenoble, France)
Email: Hugues.Lortat-Jacob@ibs.fr

Abstract available online.

(C) Nature Chemical Biology press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.