A chromosomal alteration that fuses the P2RY8 and CRLF2 genes is found in individuals with B-progenitor acute lymphoblastic leukemia (ALL) and ALL associated with Down syndrome (DS), according to a new study published online in Nature Genetics.
ALL is the most common childhood cancer, with a cure rate of 85% in children. Children with DS are approximately 10-20 times more likely to develop leukemia than non-DS children.
Charles Mullighan and colleagues report that a recurrent chromosomal deletion that leads to the P2RY8-CRLF2 fusion is found in 7% of individuals with B-progenitor ALL and 53% of individuals with Down syndrome-associated ALL. The fusion leads to elevated activity of the CRLF2 gene, which may contribute to the increased risk of ALL in children with DS.
Charles G. Mullighan (St. Jude Children's Research Hospital, Memphis, TN, USA)
Abstract available online.
(C) Nature Genetics press release.
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