home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Where is the Heritability?

  October, 16 2009 4:28
your information resource in human molecular genetics

Despite the identification of hundreds of genetic variants linked to human diseases, most variants explain a small proportion of disease risk. A review article in Nature asks what strategies should be explored to illuminate the genetics of complex diseases, and examines potential sources of missing heritability.

Heritability analyses attempt to estimate relative contributions of differences in genetic and non-genetic factors to the total phenotypic variance in a population. Genome-wide association studies (GWAS) have identified hundreds of genetic variants associated with complex human diseases and traits, and have provided valuable insights into their genetic architecture.

Teri A Manolio and colleagues, who met in February this year at a special National Human Genome Research Institute (NHGRI) workshop on missing heritability, propose research strategies, including and extending beyond current genome-wide association approaches to identify genetic variance involved in disease risk and prognosis. They argue that "although the value of genetic variants in disease prediction and the steps needed to realise this are widely debated [...] the search for missing heritability provides a potentially valuable path towards further discoveries


Teri A Manolio (National Human Genome Research Institute, Bethesda, MD, USA)
Email: manoliot@mail.nih.gov

(C) Nature press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.