home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Repairing Memory after a Sleepless Night

  November, 2 2009 8:20
your information resource in human molecular genetics

The cognitive deficits caused by sleep deprivation may be reversible by reducing the concentration of a specific enzyme in the hippocampus of the brain. The findings, reported in Nature, could present a new approach to treating the memory and learning deficits of insomnia.

Sleep deprivation afflicts millions of people and can lead to short- and long-term memory and learning problems. Ted Abel and colleagues found that sleep deprivation in mice affects an important molecular pathway in the hippocampus - a region of the brain known to be important for memory and learning. Mice deprived of sleep had increased levels of the enzyme PDE4 and reduced levels of the molecule cAMP, the latter of which is crucial in forming new synaptic connections in the hippocampus as a result of learning.

By administrating an inhibitor of PDE4 to the sleep-deprived mice, the researchers were able to reverse the decrease in cAMP concentration. This reversal also helped to rescue deficits in synaptic connections in the hippocampus and therefore counteract some of the memory consequences of sleep deprivation.


Ted Abel (University of Pennsylvania, Philadelphia, PA, USA)
E-mail: abele@sas.upenn.edu

(C) Nature press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.