home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Itching to Quit

  September, 17 2009 9:37
your information resource in human molecular genetics

Nicotine activates a channel known to be involved in inflammatory responses reports a study published online in Nature Neuroscience. This ion channel is found in the skin and the lining of the nose and mouth, and it may be the source of the irritating side effects of nicotine replacement therapies.

It had been thought that the irritation from nicotine patches and other replacement treatments resulted from the stimulation of nicotinic receptors on the nerves that convey painful stimuli from the skin and the linings of the nose and mouth. However, Talavera and colleagues report that, in mice, nicotine also directly activates TRPA1, a channel known to convey information about irritating substances and inflammatory pain. The authors also report that mice lacking TRPA1 show no irritation in response to the intra-nasal administration of nicotine.

This finding may help in the development of therapies which help stop people smoking with fewer adverse effects.

Author contact:

Karel Talavera (Katholieke Universiteit Leuven, Belgium)
E-mail: Karel.Talavera@med.kuleuven.be

Abstract available online.

(C) Nature Neuroscience press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.