Twelve new genetic variants are associated with increased risk of systemic lupus erythematosus (SLE), according to 2 independent studies published online in Nature Genetics. Together the studies increase our understanding of the genetic basis of SLE, but also highlight the differences in genetic risk factors for SLE between populations.
Systemic lupus erythematosus is a highly variable autoimmune disease in which a person's immune system attacks tissue in his or her own body. The disease course often cycles from relatively benign to more severe symptoms throughout a patient's life. The prevalence of SLE ranges from 7 to 71 cases per 100,000 people in European populations and from 31 to 70 cases per 100,000 individuals in Chinese populations.
Robert Graham and colleagues analyzed the genomes of approximately 2000 patients from the United States and Sweden and identified five new susceptibility loci that are associated with increased risk of SLE. Xue-Jun Zhang and colleagues analyzed 4000 SLE patients from China and discovered 9 new susceptibility loci for SLE, with 2 loci overlapping those found by Graham and colleagues.
Robert R. Graham (Genentech, South San Francisco, CA, USA)
Xue-Jun Zhang (Anhui Medical University, Anhui, China)
Abstracts available online:
Abstract of Paper 1.
Abstract of Paper 2.
(C) Nature Genetics press release.
Message posted by: Trevor M. D'Souza
Bookmark and Share this page (what is this?)
Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.
Use the links below to share this article on the social bookmarking site of your choice.
Read more about social bookmarking at Wikipedia - Social Bookmarking