Prostate cancer could be caused by the aberrant activity of a newly identified stem cell type, a mouse study in Nature paper suggests. The finding has implications for therapeutic design.
The rare cells, identified by Michael Shen and colleagues, are found among the epithelial cells that line the inner cavity of the prostate gland. They can form copies of themselves, and also generate different, more mature cell types - the hallmarks of a true stem cell. Critically, the team show that when a particular tumour suppressor gene is deleted in the cells, they give rise to prostate cancer in mice.
Stem cells have been suggested to underlie other forms of cancer, for example some leukaemias. The find suggests that these putative prostate stem cells can, under certain circumstances, cause prostate cancer.
Michael Shen (Columbia University Medical Center, New York, NY, USA)
Abstract available online.
(C) Nature press release.
Message posted by: Trevor M. D'Souza
Bookmark and Share this page (what is this?)
Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.
Use the links below to share this article on the social bookmarking site of your choice.
Read more about social bookmarking at Wikipedia - Social Bookmarking