home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

MicroRNA Silencing In Non-Human Primates

  April, 3 2008 8:28
your information resource in human molecular genetics

Researchers have effectively silenced microRNAs (miRNAs) in monkeys for the first time, targeting a liver-specific miRNA and reducing blood cholesterol as a result. The research is the first demonstration of miRNA silencing in primates and supports the potential of new nucleic-acid-based therapeutics, as many disease-associated genes are regulated by miRNAs.

Previous work has demonstrated that short interfering RNAs can be administered in primates to reduce expression from select messenger RNAs. Sakari Kauppinen and colleagues now show that a therapeutic effect can also be achieved by targeting miRNAs; their results are reported online in Nature. The authors synthesized a short DNA sequence composed of modified nucleotides that had complementarity to a miRNA that regulates a gene involved in cholesterol metabolism. Injection of this oligonucleotide led to a reduction in serum cholesterol without detectable toxicity in the monkeys.

The research is an important step in understanding the functions of miRNAs and in the future development of oligonucleotide-based therapeutics.


Sakari Kauppinen (Santaris Pharma, Hørsholm, Denmark)
E-mail: sk@santaris.com

Abstract available online.

(C) Nature press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2018 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.