home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

New Genetic Risk Factors For Type 2 Diabetes

  April, 3 2008 8:57
your information resource in human molecular genetics
At least six regions of the genome harbor variants that predispose to type 2 diabetes, according to a study published online in Nature Genetics.

Recent genome-wide association studies have identified genetic variants that influence risk of type 2 diabetes, although together they explain just a small fraction of the genetic contribution to the disease. A large consortium of scientists has carried out a 'meta-analysis' combining three previously published studies in order to identify additional risk factors. They found six variants to be strongly associated with type 2 diabetes, and each was replicated in an independent sample of more then 50,000 individuals. Although the particular genes affected by these variants will require additional genetic mapping, the candidates provide potential new insights into the pathogenesis of the disease.

All told the results suggest that genome scans of tens of thousands of individuals will be required to complete the picture of the genetic underpinnings of common, complex diseases.

Author contacts:

Mark McCarthy (University of Oxford, UK)
E-mail: mark.mccarthy@drl.ox.ac.uk

Michael Boehnke (University of Michigan, Ann Arbor, MI, USA)
E-mail: boehnke@umich.edu

David Altshuler (Broad Institute of Harvard and MIT, Cambridge, MA, USA)
E-mail: altshuler@molbio.mgh.harvard.edu

Abstract available online.

(C) Nature Genetics press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.