home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Colorectal Cancer Risk Variants

 
  April, 3 2008 9:00
your information resource in human molecular genetics
 
     
Three new variants are associated with increased risk of colorectal cancer, according to two studies published online in Nature Genetics. The research also uncovers the first population-specific susceptibility allele for the disease.

Malcolm Dunlop and colleagues carried out a genome-wide association study of individuals with and without colorectal cancer, and identified a variant on chromosome 11 as increasing risk of the disease by approximately 10%. The variant seems to have a stronger effect on susceptibility to rectal cancer than colon cancer. The authors also observe that Japanese individuals carrying the risk variant do not show an increased risk of colon cancer, although they do have an increased risk of rectal cancer. This is the first report of a population-specific susceptibility allele for colorectal cancer.

In a parallel study, Richard Houlston and colleagues report two new risk loci for the disease on chromosomes 8 and 10. The risk variant on chromosome 8 is near the gene EIF3H, which is known to be overexpressed in other cancers.

Author contacts:

Malcolm Dunlop (University of Edinburgh, UK)
E-mail: malcolm.dunlop@hgu.mrc.ac.uk

Richard Houlston (Institute of Cancer Research, Sutton, UK)
E-mail: richard.houlston@icr.ac.uk

Abstracts available online:

Paper 1.
Paper 2.

(C) Nature Genetics press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.