home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Molecular Clues To Appetite And Drug Addiction

  May, 28 2008 19:21
your information resource in human molecular genetics

Researchers have discovered a new molecular mechanism that underpins the brain's responses to food and drugs of abuse, such as cocaine. Mice with a particular mutation in this pathway are less enthusiastic about seeking food and show reduced responses to addictive drugs.

Both food and addictive drugs trigger the accumulation of a protein called DARPP-32 in the nuclei of brain cells involved in the brain's reward systems, report researchers led by Jean-Antoine Girault in Nature. This protein seems to be a key component of the signalling pathway by which the brain learns that such substances are pleasurable.

Girault's team also pinpoint a region of the DARPP-32 protein that seems to be critical to its function. Mice with a specific error in the sequence of amino acids that makes up this protein were less likely to show obsessive food - or drug-seeking behaviour - for example, they gave up more easily in 'nose-poke' trials, in which they have to poke a lever to get food, and the number of pokes required is then increased.


Jean-Antoine Girault (INSERM, Universite Pierre et Marie Curie, Paris, France)
E-mail: girault@fer-a-moulin.inserm.fr

Abstract available online.

(C) Nature press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.