home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Target Identified For Dengue Therapy

  May, 28 2008 19:27
your information resource in human molecular genetics

Scientists have identified a molecule targeted by dengue virus in mice to bring about the haemorrhagic fever associated with lethal disease. The research, reported online in Nature, could help the development of therapeutic agents for this and other viral diseases.

Dengue is mosquito borne and infects at least 50 million people a year, but little is known about how the virus causes disease. Shie-Liang Hsieh and colleagues show that it hijacks the CLEC5A molecule on immune cells to cause a massive release of potent inflammatory agents known as cytokines. These cytokines are probably responsible for the inappropriate inflammation that causes haemorrhagic fever.

Using antibodies to block the interaction between CLEC5A and dengue virus, the team found that they could prevent inflammation without affecting the normal immune response to virus infection. What's more, 50% of mice treated with these antibodies managed to clear the virus. This ability to control inflammation and simultaneously maintain natural viral immunity makes CLEC5A an exciting prospect for the development of treatment agents, say the authors.


Shie-Liang Hsieh (National Yang-Ming University, Taipei, Taiwan)
E-mail: slhsieh@ym.edu.tw

Abstract available online.

(C) Nature press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.