home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Therapeutic Cloning Treats Neurodegenerative Disease

 
  April, 3 2008 9:06
your information resource in human molecular genetics
 
     

Therapeutic cloning can be used to treat Parkinson's disease in mice, reports a study published online in Nature Medicine. The method may be an effective way to reduce transplant rejection and enhance recovery in other diseases and in other organ systems.

In therapeutic cloning, also known as somatic-cell nuclear transfer (SCNT), the nucleus of a somatic cell from a donor subject is inserted into an egg with the nucleus removed. This cell then develops into an embryo from which stem cells can be harvested and differentiated for therapeutic purposes. As the genetic information in the resulting stem cells comes from the donor subject, SCNT would yield subject-specific cells that would be spared by the immune system after transplantation.

Lorenz Studer and colleagues show that therapeutic cloning can treat Parkinson's disease in a mouse model. They obtained stem cells after SCNT and differentiated them into dopaminergic neurons -- the missing neurons in Parkinson's disease. The mice that received neurons derived from their own clones exhibited neurological improvement. But when these neurons were grafted into mice that did not genetically match the transplanted cells, the cells did not survive and the mice did not recover.

This is the first time that SCNT has been successfully used to treat disease in the same subjects from whom the cells were derived.

Author contact:

Lorenz Studer (Memorial Sloan Kettering Cancer Center, New York, NY, USA)
E-mail: studerl@mskcc.org

Additional co-author contact:

Tabar Viviane (Memorial Sloan Kettering Cancer Center, New York, NY, USA)
E-mail: tabarv@mskcc.org

Abstract available online

(C) Nature Medicine press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.