Two months and less than $1 million is all it takes to sequence an individual genome, according to research reported in Nature. The method makes use of the latest parallel sequencing instrument to analyse the genetic code of a single individual, James D. Watson.
Next-generation sequencing technologies are revolutionizing human genomics, promising to yield draft genomes much cheaper and faster. Involving no cloning of Watson's DNA, Jonathan Rothberg and colleagues make use of such cutting-edge technology. The sequence cost less than US$1 million and a mere two months to produce, compared to the approximately US$100 million reported for sequencing Craig Venter's genome by traditional methods. The sequence and genetic variation in it constitutes a huge resource for future discoveries, and a step towards the goal of 'personalized genomes' and 'personalized medicine'.
Jonathan Rothberg (Rothberg Institute for Childhood Diseases Research, Guilford, CT,USA)
Maynard Olson (University of Washington, Seattle, WA, USA) N&V author
(C) Nature press release.
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