home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Mutations Of The X-Linked Genes Encoding Neuroligins NLGN3 And NLGN4 Are Associated With Autism

  March, 31 2003 9:22
your information resource in human molecular genetics
Autism is characterized by impaired reciprocal social interaction and communication and stereotyped patterns of interests and activities. Asperger syndrome is characterized by higher cognitive abilities and more normal language function.

Many studies have supported a genetic etiology for autism. A Nature Genetics paper published online reports mutations in two X-linked genes encoding neuroligins NLGN3 and NLGN4 in siblings with autism-spectrum disorders. These mutations affect cell-adhesion molecules localized at the synapse. The authors hypothesize that a defect in NLGN3 or NLGN4 may abolish formation, stabilization or recognition of specific synapses essential for the communication processes that are deficient in individuals with autistic spectrum disorder.

Author contact:

Thomas Bourgeron
Laboratoire de Genetique Humaine et Fonctions Cognitives
Universite Paris 7
Institut National de la Santee r la Recherche Medicale E0021
Institu Pasteur
75015 Paris
E-mail: thomasb@pasteur.fr

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2018 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.