Neurons born in adulthood develop in a far different environment from those born in young animals, because the adult-born neurons must find their way through functioning brain circuits. Perhaps for this reason, the functional properties of adult-born neurons develop in a different order than that seen in young animals, reports a paper in the May issue of Nature Neuroscience.
New adult neurons migrate through mature neural tissue--first tangentially to the olfactory bulb and then radially to their final position. Pierre-Marie Lledo and colleagues used a clever technique to identify these newborn cells in living brain tissue. Patch-clamp recordings showed that tangentially migrating neurons expressed inhibitory GABAA and excitatory AMPA receptors. The plasticity-related NMDA receptors appeared later, in radially migrating neurons, in contrast to young tissue where NMDA receptors precede AMPA receptors. Spontaneous synaptic activity emerged soon after migration was completed. However, spiking activity did not occur until neurons were almost fully mature. This delayed maturation of excitability may serve to prevent the newborn cells from disrupting the function of circuitry already in place in the adult.
Pasteur Institute, CNRS, Paris, France
Tel: +33 1 45 68 88 03
Also available online.
(C) Nature Neuroscience press release.
Message posted by: Trevor M. D'Souza
Bookmark and Share this page (what is this?)
Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.
Use the links below to share this article on the social bookmarking site of your choice.
Read more about social bookmarking at Wikipedia - Social Bookmarking
Variants Associated with Pediatric Allergic Disorder
Mutations in PHF6 Found in T-Cell Leukemia
Genetic Risk Variant for Urinary Bladder Cancer
Antibody Has Therapeutic Effect on Mice with ALS
Regulating P53 Activity in Cancer Cells
Anti-RNA Therapy Counters Breast Cancer Spread
Mitochondrial DNA Diversity
The Power of RNA Sequencing
‘Pro-Ageing' Therapy for Cancer?
Niche Genetics Influence Leukaemia
Molecular Biology: Clinical Promise for RNA Interference
Chemoprevention Cocktail for Colon Cancer
more news ...