home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Young Neurons In Old Brains

 
  April, 21 2003 7:35
your information resource in human molecular genetics
 
     
Neurons born in adulthood develop in a far different environment from those born in young animals, because the adult-born neurons must find their way through functioning brain circuits. Perhaps for this reason, the functional properties of adult-born neurons develop in a different order than that seen in young animals, reports a paper in the May issue of Nature Neuroscience.

New adult neurons migrate through mature neural tissue--first tangentially to the olfactory bulb and then radially to their final position. Pierre-Marie Lledo and colleagues used a clever technique to identify these newborn cells in living brain tissue. Patch-clamp recordings showed that tangentially migrating neurons expressed inhibitory GABAA and excitatory AMPA receptors. The plasticity-related NMDA receptors appeared later, in radially migrating neurons, in contrast to young tissue where NMDA receptors precede AMPA receptors. Spontaneous synaptic activity emerged soon after migration was completed. However, spiking activity did not occur until neurons were almost fully mature. This delayed maturation of excitability may serve to prevent the newborn cells from disrupting the function of circuitry already in place in the adult.

Author contact:
Pierre-Marie Lledo
Pasteur Institute, CNRS, Paris, France
Tel: +33 1 45 68 88 03
E-mail: pmlledo@pasteur.fr

Also available online.

(C) Nature Neuroscience press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2016 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.