Compelling new scientific evidence suggests cancer cells can trigger changes in their immediate surroundings that promote self-preservation. Collagen VI, a protein produced by ovarian cancer cells, appears to help these cells alter their microenvironment so they are more resistant to chemotherapeutic drugs commonly used to treat the disease, according to investigators at the National Institute on Aging (NIA) Intramural Research Program and colleagues at other research centers.
The findings* are reported in the April 2003 issue of Cancer Cell.
*CA Sherman-Baust, AT Weeraratna, LBA Rangel, ES Pizer, KR Cho, DR Schwartz, T Shock, and PJ Morin, "Remodeling of the Extracellular Matrix Through Overexpression of Collagen VI Contributes to Cisplatin Resistance in Ovarian Cancer Cells, Cancer Cell, Vol. 3, Issue 4, pp. 377-386.
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