Using the right combination of molecules is the key to creating stable blood vessels, report Yihai Cao and colleagues in the May issue of Nature Medicine. This advance could be critical in treating the effects of ischemia, where damaged blood vessels cut off blood supply to limbs or heart muscle.
Using angiogenic factors--which stimulate the growth of new blood vessels--on their own can cause serious complications. The factors can lead to new blood vessels that may be leaky or unstable. Among the natural growth factors tested by Cao and co-workers, only platelet-derived growth factor-BB and fibroblast growth factor-2 worked together to establish fully functional, long-lasting networks of blood vessels in rat and rabbit models.
The new vessels remained stable for more than a year, even after researchers removed the angiogenic factors. The findings will be an important consideration when designing angiogenic therapies, the researchers say.
Laboratory of Angiogenesis Research
Microbiology and Tumor Biology Center
Karolinska Insitutet, Stockholm
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Also published online.
(C) Nature Medicine press release.
Message posted by: Trevor M. D'Souza