home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Dysfunctional Gene Dooms Ovarian Tumors

 
  April, 7 2003 8:27
your information resource in human molecular genetics
 
     
Small alterations in a gene required for responding to chemotherapy can result in drug-resistant ovarian cancer, Alan D'Andrea and his colleagues report in the May issue of Nature Medicine.

In the United States alone, there are approximately 23,000 new cases of ovarian cancer diagnosed per year, and more than 15,000 women die from the disease. Ovarian cancer cells are initially sensitive to chemotherapeutic drugs such as cisplatin but, by an unknown mechanism, become resistant to the drugs over time. Understanding how the cells become resistant could lead to new drugs to treat the cancer, the researchers say.

The researchers examined the Fanconi anemia-BRCA pathway, which regulates sensitivity to cisplatin, in ovarian tumor cells. They found that the pathway is disrupted in some ovarian tumors and identified an early event -- the removal of methyl groups from a critical gene in the pathway -- that causes cisplatin resistance.

Author contact:

Alan D. D'Andrea
Division of Pediatric Oncology
Dana-Farber Cancer Institute
Boston, MA
USA
Tel: +1 617 632 2080
E-mail: alan_dandrea@dfci.harvard.edu

Also available online.

(C) Nature Medicine press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2016 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.