home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Alzheimer’s Disease Peptide Acts At A Distance

  February, 24 2003 9:28
your information resource in human molecular genetics
Beta amyloid peptide from diseased neurons can form pathological protein deposits and cause neurodegeneration in nearby normal tissue, reports a study in the April issue of Nature Neuroscience. The results suggest that amyloid outside cells, rather than within neurons, may be the type that is detrimental in Alzheimer's disease.

An international group of authors from Switzerland, Belgium and the US used transgenic mice that express a mutated version of the Alzheimer's precursor protein (the source of beta amyloid) to study the formation of abnormal protein deposits called ‘plaques’, which are a symptom of Alzheimer’s disease. They found plaques within grafts of normal tissue placed into the brains of mutant mice, suggesting that amyloid from outside the graft was able to diffuse in and form plaques. These normal tissue grafts also showed other signs of amyloid pathology and neurodegeneration. In contrast, when neuronal tissue from mutant mice was grafted into the brains of normal mice, no plaques were formed.

These results address a long-debated question of whether the amyloid is problematic when it is first produced within neurons or whether extracellular accumulation into plaques is the first step toward pathology. Although intracellular effects cannot be ruled out, it is clear from these results that extracellular amyloid is sufficient to induce plaque formation and other amyloid-associated pathologies.

Author contact:
Mathias Jucker
Department of Neuropathology
University of Basel, Switzerland
Tel: +41 61 265 28 94
E-mail: mjucker@uhbs.ch

Additional contact for comment on paper:
David R. Borchelt
Department of Pathology
Johns Hopkins University School of Medicine
Baltimore, MD
Tel: +1 410 502 5174
E-mail: drbor@jhmi.edu

Also published online.

(C) Nature Neuroscience press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.