home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Genetic Variant Associated With Susceptibility To Osteoarthritis

 
  April, 5 2007 8:20
your information resource in human molecular genetics
 
     
A variant in a gene called GDF5 is associated with the risk of developing osteoarthritis, a study published online in Nature Genetics suggests. Osteoarthritis is the most common form of arthritis, affecting more than 20 million people in the United States.

Osteoarthritis is caused by the breakdown and loss of the cartilage in one or more joints during ageing, leading to swelling, pain, and limited mobility. Shiro Ikegawa and colleagues analyzed variation across the GDF5 gene and found that one particular variant was significantly more frequent in two independent populations of Japanese individuals with osteoarthritis of the hip compared to disease-free individuals. The same variant was also found to be significantly more frequent in both Japanese and Chinese individuals suffering from osteoarthritis of the knee. Depending on the study, the variant conferred 30%-80% additional risk of developing the disease. The authors showed that this variant probably reduces the amount of GDF5 produced. As GDF5 is a protein that is secreted by cells and is known to be involved in cartilage development, lower levels of GDF5 may affect the maintenance of cartilage in joints.

Author contact:

Shiro Ikegawa (SNP Research Center, RIKEN, Tokyo, Japan)
E-mail: sikegawa@ims.u-tokyo.ac.jp

Abstract available online.

(C) Nature Genetics press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.