home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

New Way Of Targeting Gene To Treat Breast Cancer

 
  March, 8 2007 10:21
your information resource in human molecular genetics
 
     
A new way of targeting the PARP1 gene in order to induce cell death in breast cancer cells is reported online in Cell Death and Differentiation. The study provides alternative possibilities for breast cancer treatment following safety concerns raised by previous studies involving Parp1-deficient mice.

The BRCA1 gene mutation causes approximately half the cases of familial breast cancer. Loss of the PARP1 gene in BRCA1-mutated cells leads to apoptosis, the programmed death of a cell. PARP1 inhibitors have therefore been proposed as a promising treatment for breast cancer. However, an earlier investigation revealed that the deletion of this gene in mice actually induces breast cancer, causing worries over the safety of this type of treatment.

Chu-Xia Deng and colleagues now reveal that the haploid loss of this gene - the loss of just one of the two gene copies - is sufficient to induce apoptosis in BRCA1-mutated cells in mice. This discovery means that drugs that lead to only the partial inhibition of PARP1 could serve as an effective and safer treatment of BRCA1-associated breast cancer.

Author contacts:

Chu-Xia Deng (National Institute of Health, Bethesda, MD, USA)
E-mail: chuxiad@bdg10.niddk.nih.gov

Editorial contact:

Rachel Gonzaga (Cell Death and Differentiation, London)
E-mail: r.gonzaga@nature.com

Abstract available online.

(C) Cell Death and Differentiation press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.