home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Laying Sleeping Sickness To Rest

 
  March, 21 2007 9:18
your information resource in human molecular genetics
 
     
The parasite that leads to sleeping sickness can be lulled to sleep itself using a newly discovered pathway, according to research published online in EMBO reports. Trypanosoma brucei is a parasite that causes sleeping sickness resulting in neurological damage and death.

Shulamit Michaeli and colleagues describe a pathway in T. brucei parasites that they named SLS (SL-RNA silencing). Triggering this pathway shuts down the synthesis of a crucial RNA molecule, which halts the production of messenger RNAs and leads to the parasite's death. Inducing SLS could therefore be a novel way to eradicate parasites and prevent sleeping sickness - trypanosomiasis. The researchers also believe this could have implications for related parasites and diseases, such as Leishmania and leishmaniasis and Trypanosoma cruzi and Chagas disease.

Sleeping sickness affects humans and livestock, and is endemic in sub-Saharan Africa where it is estimated to affect as many as 70,000 people. Leishmaniasis is estimated to affect millions of individuals throughout the world, and can lead to skin lesions, tissue damage, fever, blindness and death. Chagas disease affects 16-18 million people across the Americas, and can cause intestinal complications, neurological disorders, heart damage and death. Although drugs are available to treat these diseases, their use is hampered by toxicity and undesirable side effects, difficulties in administering treatment, an increase in drug resistance, and high costs.

Author contact:

Shulamit Michaeli (Bar-Ilan University, Ramat-Gan, Israel)
E-mail: michaes@mail.biu.ac.il

Editorial contact:

Sandra Caldeira (EMBO reports, Germany)
E-mail: emboreports@embo.org

Abstract available online.

(C) EMBO press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.