Scientists have identified unforeseen mechanisms by which quinolones - a family of broad-spectrum antibiotics among the most widely prescribed - induce bacterial cell death. The study is published online in Molecular Systems Biology.
It is well-known that quinolones inhibit bacterial DNA gyrase - an enzyme essential to DNA replication - and induce cell death by stimulating DNA damage, impeding lesion repair and blocking replication processes. Using a systems biology approach, Jim Collins and colleagues reveal that, in addition to the expected DNA damage response, gyrase inhibition surprisingly triggers a genetic program characteristic of responses to oxidative stress and promotes the generation of deleterious hydroxyl radicals. The authors confirm their findings by showing that chemical or genetic prevention of gyrase inhibitor-induced oxidative damage protects from the bactericidal action of quinolone antibiotics. This work will facilitate the identification of antibacterial therapies with improved bactericidal activity.
Jim Collins (Boston University, MA, USA)
Thomas Lemberger (Molecular Systems Biology, Germany)
Article available online.
(C) Molecular Systems Biology press release.
Message posted by: Trevor M. D'Souza
Bookmark and Share this page (what is this?)
Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.
Use the links below to share this article on the social bookmarking site of your choice.
Read more about social bookmarking at Wikipedia - Social Bookmarking