home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

A Potential Therapeutic Agent For Retinoblastoma

  March, 21 2007 9:26
your information resource in human molecular genetics
A natural agent derived from the bark of the South-American lapacho tree inhibits growth and induces cell death in human retinoblastoma cell lines, according to a paper published online in Eye. Beta-lapachone induces potent cytotoxic effects at low micromolar concentrations, which the authors suggest might lead to its use in the clinical management of retinoblastoma.

Retinoblastoma is a childhood cancer that accounts for approximately 3% of cancers in children. In the developing world it remains fatal, however in developed countries it is one of the most curable paediatric cancers, combated using a combination of therapies. One problem that exists with the traditional approach of radiotherapy is the association of long-term morbidity and even secondary mortality. A preferred option would be chemotherapy together with a locally applied therapeutic modality, such as laser therapy or cryotherapy.

Heeral Shah and colleagues investigated the effects of beta-lapachone on human retinoblastoma cell lines. They found that beta-lapachone was effective in inhibiting the growth and proliferation of retinoblastoma cells, and actively induced their apoptotic destruction at low doses. Their findings are consistent with those from studies of the effect of beta-lapachone in other human cancer cell lines - including breast, colon and lung cancer. Given recent reports that beta-lapachone also acts with a high degree of selectivity towards cancer cells, the authors suggest that it could have great utility in the management of retinoblastoma.

Author contact:

Joan O'Brien (University of California, San Francisco, CA, USA) Co-author
E-mail: joan.obrien@ucsf.edu

Editorial contact:

Emma Greenwoord (Assistant Editor, Nature Publishing Group)
E-mail: emma.greenwood@nature.com

Abstract available online.

(C) Eye press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.