home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Sperm DNA Packaging

  June, 19 2009 7:40
your information resource in human molecular genetics

A paper in Nature provides insights into how DNA in sperm is packaged during development, which could reflect the role the paternal genome has in the embryo.

During sperm development, the proteins that are used to package DNA, known as histones, are mostly exchanged for protamines -- small basic proteins that form tightly packed DNA structures important for normal sperm function. Whether the rare histones that are not exchanged have any function or are simply randomly distributed remnants has until now been unclear. Bradley Cairns and colleagues used high-resolution genomic approaches to map the histones retained in mature human sperm. Histones are found to be significantly enriched at developmentally important genes and to have distinctive patterns of modification. Therefore, these histones might have been retained for a reason, to perform specific functions in the embryo.

Author contact:

Bradley Cairns (University of Utah School of Medicine, Salt Lake City, UT, USA)
E-mail: brad.cairns@hci.utah.edu

Abstract available online.

(C) Nature press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2021 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.