home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Genetic Variants Associated With Schizophrenia

 
  July, 2 2009 8:58
your information resource in human molecular genetics
 
     

Three papers in Nature provide new insights into genetic variation and schizophrenia risk. Using combined data from three large cohorts, the papers jointly reveal significant associations to individual loci that implicate immunity, cognition and brain development. Additionally, one of the papers provides genetic evidence for a substantial polygenic component to risk of schizophrenia that also contributes to risk of bipolar disorder.

Pamela Sklar and the International Schizophrenia Consortium show that common genetic variation underlies risk of schizophrenia. Their study identifies common variants within the major histocompatibility complex (MHC) locus, and provides molecular genetic evidence for a substantial polygenic component to risk of schizophrenia that involved thousands of common alleles of very small effect. These alleles of small effect also contribute to risk of bipolar disorder.

Kari Stefansson and colleagues present a genome-wide association of single nucleotide polymorphisms (SNPs) and reveal significant associations to individual loci that implicate immunity, brain development, memory and cognition in predisposition to schizophrenia.

Pablo Gejmans and the Molecular Genetics of Schizophrenia use a case-control study design to show an association between the MHC genomic locus and schizophrenia. Their results suggest a possible involvement of chromatin proteins in this disorder.

Together, by using meta-analysis of almost 10,000 cases and 20,000 controls, these three studies indicate that although common genetic variation that underlies risk to schizophrenia can be identified, there are probably few or no single common loci with large effects.

CONTACT

Pamela Sklar (Massachusetts General Hospital, Boston, MA, USA) Author paper [1]
E-mail: sklar@chgr.mgh.harvard.edu

Kari Stefansson (DeCODE Genetics, Regykjavik, Iceland) Author paper [2]
E-mail: edward.farmer@decode.is

Pablo Gejman (NorthShore University HealthSystem Research Institute, Evanston, IL, USA) Author paper [3]
E-mail: pgejman@mac.com

Abstracts available online:
Abstract of Paper 1.
Abstract of Paper 2.
Abstract of Paper 3.

(C) Nature press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.