home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Evolution of a Malaria Resistance Gene in Wild Primates

 
  July, 2 2009 8:50
your information resource in human molecular genetics
 
     

A genetic variation has been linked to the emergence of malaria resistance in wild baboons, the first time that a specific DNA change has been linked to a complex trait in a natural population of non-human primates. The results, reported in Nature, suggest that the genetic basis of complex traits may show parallels across different primate species.

Jenny Tung and colleagues analysed blood samples from 190 yellow baboons (Papio cynocephalus) living in Kenya's Amboseli National Park. Six single-base-pair changes were spotted in a regulatory region of the malaria-related FY gene. Genetic variation in this region was associated with variation in susceptibility to a malaria-like pathogen and also influenced gene expression in vivo in wild animals.

Understanding the ecology, behaviour and genetics of non-human primates should shed light on our own evolution, yet functional genetic analyses like this one are rare. This study suggests that the evolution of malaria resistance in wild baboons shares mechanistic and evolutionary parallels with the similar genetic region in humans.

CONTACT

Jenny Tung (Duke University, Durham, NC, USA)
E-mail: jt5@duke.edu

Abstract available online.

(C) Nature press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.