home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Cancer Protein May Prove Useful Biomarker

 
  July, 2 2009 8:54
your information resource in human molecular genetics
 
     

A new cancer-causing gene with biomarker potential is revealed in Nature.

The gene encodes a protein called GOLPH3, which is found in a stacked cellular organelle known as the Golgi apparatus. GOLPH3 has previously been found to be amplified in many human tumours. Lynda Chin and colleagues now show that expressing more of this protein activates the mTOR signalling pathway, implicated in nearly all cancers, and makes mouse and human cells become cancerous. However, having more GOLPH3 also renders cancer cells more sensitive to the cancer drug rapamycin, which works by inhibiting the mTOR pathway.

Drugs that target the mTOR pathway are currently an intense focus of cancer drug development, but the clinical response to rapamycin and its analogues has been feeble. The authors hope that GOLPH3 levels may help predict sensitivity to mTOR inhibitors, but the protein's predictive value as a biomarker has yet to be demonstrated.

CONTACT

Lynda Chin (Dana-Farber Cancer Institute, Boston, USA)
E-mail: lynda_chin@dfci.harvard.edu

(C) Nature press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.