home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Glutamate Receptors And Schizophrenia

 
  March, 6 2006 1:36
your information resource in human molecular genetics
 
     
The glutamatergic system is the most common excitatory neurotransmitter system in the central nervous system. N-methyl-D-aspartate (NMDA) receptors form an integral part of this system, and their dysregulation has been linked to the aetiology of numerous psychiatric phenotypes. Mounting evidence from pharmacology, postmortem studies, clinical interventions, and animal models indicates that the genes encoding these NMDA receptors, particuarly GRIN1 and GRIN2A, may play an important role in susceptibility to schizophrenia.

In a study to be published in the journal Biological Psychiatry, Xinzhi Zhao and colleagues from the Shanghai Institute of Mental Health have genotyped numerous polymorphisms in both genes in a large sample of 2455 Han Chinese subjects. A highly significant association was detected at the 5′ end of the GRIN1 gene. Analysis of single variants and multiple-locus haplotypes indicates that the association is mainly mediated by the single nucleotide polymorphism (SNP) rs11146020, which was found to be strongly associated with schizophrenia. No association was found with polymorphisms in the GRIN2A gene, suggesting that this locus may not play a role in schizophrenia.

These results provide support for the hypothesis that NMDA receptors are an important factor in the development of schizophrenia. It is interesting that SNP rs11146020 is located in 5′ untranslated region of GRIN1, and the authors speculate that it may influence gene expression by affecting transcription, the stability of mRNA, or translational efficiency.

Link to article


Message posted by: Jonathan Mill

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.