The authors (Samuels et al., American Journal of Human Genetics, 78:713-720, 2006) used a simulation-based (Monte Carlo) permutation test to generate power curves for European mtDNA haplogroup studies, to derive a universal equation to enable power calculations for prospective studies across the globe, and to show that very large cohorts are required to reliably detect an association with complex human diseases.
Patrick F. Chinnery
School of Neurology, Neurobiology and Psychiatry, Mitochondrial Research Group, and Institute of Human Genetics, The University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom.
Abstract available online.
(C) 2006 by The American Society of Human Genetics.
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