|
|
|
The human caspase-12 gene is polymorphic for the presence or absence of a stop codon, which results in the occurrence of both active (ancestral) and inactive (derived) forms of the gene in the population. The researchers investigated whether the inactive form has spread because of neutral drift or positive selection (Xue et al., American Journal of Human Genetics, 78:659-670, 2006). They suggest that the inactive form of the gene arose in Africa 100–500 thousand years ago (KYA) and was initially neutral or almost neutral but that positive selection beginning 60–100 KYA drove it to near fixation.
Author Contact: Chris Tyler-Smith
The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom. Abstract available online. (C) 2006 by The American Society of Human Genetics. Posted by: Tressie Dalaya
Message posted by: Trevor M. D'Souza
|
|
Variants Associated with Pediatric Allergic Disorder
Mutations in PHF6 Found in T-Cell Leukemia
Genetic Risk Variant for Urinary Bladder Cancer
Antibody Has Therapeutic Effect on Mice with ALS
Regulating P53 Activity in Cancer Cells
Anti-RNA Therapy Counters Breast Cancer Spread
Mitochondrial DNA Diversity
The Power of RNA Sequencing
‘Pro-Ageing' Therapy for Cancer?
Niche Genetics Influence Leukaemia
Molecular Biology: Clinical Promise for RNA Interference
Chemoprevention Cocktail for Colon Cancer
more news ...
|