home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Identifying The CRAC In Immunity

  April, 12 2006 9:05
your information resource in human molecular genetics
A key protein involved in triggering the immune response against pathogens is described in a paper published online on April 02, 2006, by Nature. The immune response relies on the movement of calcium ions through specific CRAC channels in T cells. However, CRAC channel function is defective in patients with hereditary severe combined immune deficiency (SCID) syndrome.

Anjana Rao and her colleagues set out to identify the underlying genetic defect in SCID patients using a combination of two unbiased genome-wide approaches: single-nucleotide polymorphism arrays and a Drosophila RNA interference screen. Both methods identified a protein called Orai1. The authors show that SCID patients are homozygous for a mutation in the gene encoding Orai1. When wild-type Orai1 is expressed in T cells from SCID patients, CRAC channel function is restored. The authors propose that Orai1 is either an essential regulator or a component of the CRAC channel complex.


Anjana Rao (Harvard Medical School & CBR Institute for Biomedical Research, Boston, MA, USA)
E-mail: arao@cbr.med.harvard.edu

(C) Nature press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.