home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Household Allergens Make Skin Vulnerable To Eczema

 
  March, 6 2008 10:44
your information resource in human molecular genetics
 
     

Dust mite and cockroach allergens aggravate the symptoms of eczema and similar diseases by disrupting skin barrier function, a study published online in the Journal of Investigative Dermatology reports. The work provides a crucial step in understanding how the skin's defenses are weakened by allergens it encounters daily.

Over fifteen million Americans suffer from eczema, a chronic skin condition characterized by dry patches of extremely itchy skin. The most common form, atopic dermatitis affects between 10 and 20 percent of the world's population at some point during childhood. This study offers new insights into how common environmental triggers could contribute to this condition.

Using human volunteers, Seung Hun Lee and colleagues show that topically applied mite and cockroach allergens slowed skin barrier permeability recovery independent of an allergic response. The biological activity of mite and cockroach allergens disrupts skin permeability by activating PAR-2, a key receptor involved in maintaining skin barrier balance. Loss of skin barrier function causes increased inflammation and sensitivity to microbes and allergens. By delaying skin barrier restoration, mite and cockroach allergens could make the skin more susceptible to additional allergens and consequently trigger relapsing eczema lesions.

Author contact:

Seung Hun Lee (Yonsei University College of Medicine, Seoul, Korea)
E-mail: ydshderm@yumc.yonsei.ac.kr

Abstract available online.

(C)Journal of Investigative Dermatology press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.