home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Damage Limitation

 
  March, 20 2008 8:39
your information resource in human molecular genetics
 
     

A key regulator of the DNA damage response is directly activated by the transcription factor FOXO3a - a protein known to regulate the cell cycle and cell death - according to a study published in Nature Cell Biology. The results provide crucial implications for research into ageing and cancer.

All cells are subject to the relentless bombardment with from environmental stresses that damage DNA, such as UV light, ionizing radiation and various chemicals. Mammalian cells have developed intricate systems both to repair the resulting damage and to stop the proliferation of damaged cells to allow for repair or the destruction of irreversibly damaged cells. Cells that escape these safeguards undergo genomic instability, a hallmark of cancer. Two key regulators of this DNA damage response are the FOXO family, which regulates the cell cycle and cell death, and a protein kinase known as ATM, which orchestrates the recruitment of DNA repair proteins at sites of damage. How ATM is activated by various flavours forms of DNA damage is an area of intense study.

Mickey Hu and colleagues, have now uncovered a direct connection between these two key regulators of the DNA damage response. One particular FOXO family member, FOXO3a, specifically binds to ATM, leading to its activation. Inhibition of FOXO3a blocks activation of ATM and hence the DNA damage response programme. Although it remains unclear how exactly FOXO3a is itself activated by DNA damage, these results connect two key players in this crucial safety mechanism, with implications for research into ageing and cancer.

Author contact:

Mickey Hu (University of Texas, Houston, TX, USA)
E-mail: michu@mdanderson.org

Abstract available online.

(C) Nature Cell Biology press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.