home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

SARS Virus Entry Into Cells Involves Lipid Rafts

  February, 7 2008 10:38
your information resource in human molecular genetics

Lipid rafts have a key role when host cells are invaded by the SARS virus, suggests a paper published online in Cell Research. The rafts - cholesterol-enriched sections of the cell membrane - could be a potential target for treating SARS by blocking virus entry into cells.

Recent studies have disagreed about how the SARS virus enters host cells. Chengyu Jiang and colleagues use a different approach to show that it infiltrates cells through receptor-dependent, pH-sensitive endocytosis - a process whereby the cell membrane folds inwards and engulfs substances in order to take them into the cell. They show that the specific endocytic pathway used to do this is independent of the protein clathrin and the small vesicles of the plasma membrane known as caveolae, but rather it involves lipid rafts.

SARS emerged as a global epidemic in winter 2002-2003, leading to more than 700 deaths and 8,000 probable diagnoses. Re-emergence of SARS remains a global threat, and many pathological aspects of this virus are still uncharacterized. These new insights point to a potential way of treating SARS by inhibiting virus entry.

Author contact:

Chengyu Jiang (Peking Union Medical College, Beijing, China)
E-mail: jiang@pumc.edu.cn

For FREE original article, click here.

(C) Cell Research press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.