Understanding the structure of proteins involved in inhibiting HIV-1 infection could help in the battle against the disease, and in Nature researchers take a crucial step in this direction. The structure of this DNA deaminase will help researchers to understand the functions of related molecules that interact with pathogens such as HIV-1.
Reuben Harris and colleagues report the nuclear magnetic resonance structure of a domain of APOBEC3G - a single-strand DNA deaminase that inhibits the replication of HIV-1 and other retroviruses. The work contributes towards defining the whole protein and its interaction with the viral protein Vif, which could benefit the development of AIDS therapeutics that modulate this battle between host and pathogen.
Reuben Harris (University of Minnesota, Minneapolis, MN, USA)
Abstract available online.
(C) Nature press release.
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