home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Missing Cells To Blame In Job's Syndrome

  March, 20 2008 8:32
your information resource in human molecular genetics

Immunologists have made a breakthrough in understanding a rare immune disease called Job's syndrome - so called because its symptoms include recurring outbreaks of abscesses similar to the boils suffered by the eponymous Biblical character. The new research shows that sufferers lack a specific type of white blood cell, leaving them open to repeated attack by certain bacterial and fungal pathogens.

Writing online in Nature, a team led by Daniel Douek describes how sufferers of Job's syndrome, more properly called hyper-IgE syndrome (HIES), are unable to produce cells called TH17 helper cells. These immune cells produce a protein called interleukin-17, and are crucial for protection against invading pathogens.

The discovery ties in with the fact that sufferers are known to have defects in a gene called stat3, which is involved in the differentiation of TH17 cells, a common type of white blood cell, into their various specific types. The lack of this particular component of the immune system explains why patients experience repeated infections by the same pathogens, particularly fungal infection and Staphylococcus bacteria.


Daniel Douek (National Institute of Health, Bethesda MD, USA)
E-mail: ddouek@nih.gov

Abstract available online.

(C) Nature press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.