home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Coping with Immune Cell Death

 
  September, 18 2008 8:30
your information resource in human molecular genetics
 
     

Researchers have discovered a 'sensor' molecule that alerts the immune system to the presence of necrotic cells. The work, described online in Nature Immunology, shows how the body prevents excessive inflammation caused by non-infectious injuries and prevents uncontrolled tissue damage.

Poisons, ultraviolet light, radiation and other non-infectious injuries can lead to inflammation and necrosis -the unnatural death of cells and tissue material. Takashi Saito and colleagues find that a receptor molecule called Mincle, expressed by macrophages, functions as a direct sensor for this type of cell death.

Mincle detects internal components of necrotic cells that are released into the surrounding milieu. This drives macrophages to produce a chemical signal, interleukin 8 that promotes infiltration of white blood cells called neutrophils into necrotic tissues. The neutrophils then help resolve inflammation caused by the necrotic debris.

Author contact:

Takashai Saito (RIKEN Research Center for Allergy and Immunology, Yokohama, Japan)
E-mail: saito@rcai.riken.jp

Abstract available online.

(C) Nature Immunology press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2018 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.