A new genetic variant has been implicated in risk of restless legs syndrome, according to a study published online in Nature Genetics.
Restless legs syndrome is a neurological disorder characterized by pain in the lower limbs and the frequent urge to move, which leads to sleep disturbance. Juliane Winkelmann and colleagues show that a variant in the gene PTPRD is associated with increased risk of the disorder in several populations of affected individuals. PTPRD encodes one of a family of enzymes called protein tyrosine phosphatases, and this particular phosphatase has been shown in mice to function in the development of neurons that directly or indirectly control movement.
Juliane Winkelmann (Max Plancke Institute of Human Genetics, Munich, Germany)
Abstract available online.
(C) Nature Genetics press release.
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