home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Telomerase Structure Revealed

 
  September, 3 2008 7:37
your information resource in human molecular genetics
 
     

Researchers have snuck a peak at the engine of telomerase, an important enzyme that aids chromosome stability.

In Nature, Emmanuel Skordalakes and colleagues present the high resolution, and long sought-after, structure of the catalytic subunit of telomerase. The enzyme adds DNA repeats to the ends of chromosomes, preventing them from becoming shorter with each cell division. Using modeling, it is possible to predict how single-stranded telomeric DNA and the RNA subunit of telomerase align and position the DNA primer at the active site.

Understanding the mechanism of telomerase activity will affect fields such as oncology, because telomerase is reactivated in many human cancers, and ageing, because the natural loss of telomerase activity with age causes cells to enter a state known as senescence, in which they can no longer divide.

Author contact:

Emmanuel Skordalakes (The Wistar Institute, Philadelphia, PA, USA)
E-mail: skorda@wistar.org

Abstract available online.

(C) Nature press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2018 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.