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The fight against cancer takes a step forward with the online publication of a 50 page review on p53 in Cancer Gene Therapy.
This offers the most up-to-date and comprehensive analysis of cutting-edge research into this fundamental molecule involved in almost all cancers. p53 is an important protein that regulates cell proliferation and, in its mutated form, has been found in almost all types of cancers. Magali Olivier, Pierre Hainaut and their colleagues consider 78 papers on the subject*. The review examines how the different parts of the p53 molecule contribute to its overall activity and its role in upstream and downstream regulatory pathways critical to maintain normal tumour suppressor function. The role of specific p53 mutations and mechanisms of p53 inhibition which result in cancer pathogenesis and treatment resistance are also considered. The extensive integration of this knowledge highlights possible applications of the research that will be of direct benefit to cancer patients, by improving detection, prognosis, prevention and therapy. Author contact: Magali Olivier (International Agency for Research Against Cancer, Lyon, France)
E-mail: molivier@iarc.fr Abstract available online.
* The papers summarize the major findings presented at the 3rd International Workshop on Mutant p53 held at the International Agency for Research Against Cancer (IARC).
(C) Cancer Gene Therapy press release.
Message posted by: Trevor M. D'Souza
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