home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Inherited Risk Factors For Common Leukemia

  September, 3 2008 7:41
your information resource in human molecular genetics
Scientists have produced the first unequivocal evidence for inherited factors that contribute to susceptibility to chronic lymphocytic leukemia (CLL), reports a paper online in Nature Genetics. Approximately 25% of all individuals with leukemia have this form of the disease.

CLL results from the abnormal proliferation of B cells -- a type of white blood cell that originates in the bone marrow. While it is known that individuals with a family history of CLL are at higher risk, the genetic basis of this risk has not been defined.

Richard Houlston and colleagues carried out a genome-wide association study of individuals with CLL, followed up by replication attempts in two additional groups. They found six common variants that modestly increase risk of the disease. Three of these variants are in or near genes that are good candidates for involvement in CLL, based on their known functions in B cells. Individuals with all six variants are estimated to have an eightfold elevated risk of disease. The authors suggest that these variants may influence the risk of other disorders of B-cell proliferation as well.

Author contact:

Richard Houlston (Institute of Cancer Research, Sutton, UK)
E-mail: richard.houlston@icr.ac.uk

Abstract available online.

(C) Nature Genetics press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.