home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Towards A Complete Human 'Epigenome'

  November, 9 2006 8:52
your information resource in human molecular genetics
The DNA methylation profile of three human chromosomes is reported in a study to be published in the December 2006 issue of Nature Genetics, marking substantial progress towards a complete accounting of the human 'epigenome', the collection of modifications to the human genetic code that occur without changing the original DNA sequence.

DNA methylation refers to the chemical modification of DNA by the addition of methyl groups, which consist of one carbon and three hydrogen atoms. This process can affect the expression of nearby genes, usually silencing or switching them off, and is potentially an important factor in the development of some cancers when it occurs aberrantly. The Human Epigenome Project (a consortium that includes the Welcome Trust Sanger Institute, UK; Epigenomics AG, Germany; and The Centre National de Génotypage, France), whose goal is to catalog all of the sites of methylation in the human genome in all major tissues, have now done so in 12 different tissues for chromosomes 6, 20 and 22.

In addition to providing the catalog as a publicly available resource for other investigators, the authors also report that there are only very small differences in the methylation patterns between male and females and between young and old individuals. Significant differences were observed between different tissues, however.

Finally, by examining some of the corresponding regions in the mouse genome, they concluded that the pattern of methylation has been generally conserved during evolution, at least among mammals.

Author contacts:

Florian Eckhardt (Epigenomics AG, Berlin, Germany)
E-mail: florian.eckhardt@epigenomics.com

Stephan Beck (Wellcome Trust Sanger Institute, Hinxton, UK)
E-mail: beck@sanger.ac.uk

Abstract available online.

(C) Nature Genetics press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.