home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Protein For Optical Clarity

  October, 27 2006 14:22
your information resource in human molecular genetics
The presence of a protein called soluble VEGF receptor-1 (sVEGFR-1) maintains optical clarity by keeping the cornea free of blood vessels, a paper published online by Nature suggests. The discovery may aid the development of drugs that block blood vessel development, which may prove useful in cancer treatment.

Jayakrishna Ambati and colleagues found that when levels of sVEGFR-1 are reduced, blood vessels begin to grow into the eye's outer surface. And the protein is lacking in some patients with aniridia, a condition in which the cornea becomes vascularized.

Only one type of organism - the manatee - is known to have blood vessels in its cornea, and is deficient in corneal sVEGFR-1. But elephants (a close relative of the manatee), mice and humans all have significant levels of the protein, suggesting that it has been conserved through evolution.


Jayakrishna Ambati (University of Kentucky, Lexington, KY, USA)
E-mail: jamba2@uky.edu

Balamurali Ambati (Medical College of Georgia, Augusta, GA, USA)
E-mail: bambati@mail.mcg.edu

Abstract available online.

(C) Nature press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.