home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Insulin-Producing Cells From Human Embryonic Stem Cells

 
  October, 27 2006 14:26
your information resource in human molecular genetics
 
     
The culture conditions under which human embryonic stem cells can be converted into cells that produce all five hormones made by the pancreas, including insulin, are reported online in Nature Biotechnology. Baetge and colleagues' study suggests that the possibility of turning human embryonic stem cells into pancreatic cells that can be used for diabetes therapy has moved one step closer to reality.

Human embryonic stem cells have the potential to become virtually any cell type in the body. Thus, they are a promising source of cells to repair damaged organs like the pancreas, heart and liver. The challenge facing scientists is to unlock the secrets of how to produce particular cell types, such as pancreatic beta-cells - the insulin-secreting cells in the pancreas - with high efficiency.

Baetge and colleagues show that the efficient generation of insulin-producing cells from human embryonic stem cells depends on guiding the cells through stages similar to those of pancreatic development, including the critical early developmental stage known as 'definitive endoderm.' The insulin-producing cells the authors created contained high levels of insulin. They were also capable of secreting insulin, but only minimally in response to sugar - a crucial function of adult beta-cells. Thus, the cells seem closer to immature, fetal beta-cells. The authors speculate that, with additional research, these cells have the potential to be matured into insulin-producing cells that could be suitable for transplantation into patients.

Author contact:

E Edward Baetge (Novocell Inc., San Diego, CA, USA)
ebaetge@novocell.com

Abstract available online.

(C) Nature Biotechnology press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.