In a study reported in Gene Therapy (Vol. 13, pp. 1603-1610, 2006), and published online on 20 July 2006, the authors (Si et al.) used Staphylococcus enterotoxin A (SEA), a powerful immunostimulant, fused with CD80 transmembrane region (named as SEAtm) driven by alpha-fetoprotein (AFP) enhancer/promoter to reduce toxicity and to improve safety and efficiency in the application of SEA.
They demonstrated that SEAtm by adenovirus from the AFP enhancer/promoter (AdAFPSEA) could be expressed on the surface of AFP-producing cell line Hepa1-6 instead of non-AFP-producing cell lines. These findings suggest that membrane-expressed SEA by adenovirus from AdAFPSEA can generate stronger local and systemic antitumor responses against Hepatocellular Carcinoma.
Professor Y Sui, State Key Laboratory of Cancer Biology, Department of Pathology, XiJing Hospital, Fourth Military Medmedical University, Xi'an 710032,
Abstract available online.
(C) Gene Therapy.
Posted by: Tressie Dalaya
Message posted by: Trevor M. D'Souza