home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

An Unexpected Regulatory Role For Seladin-1

 
  December, 7 2004 8:53
your information resource in human molecular genetics
 
     
A new component of the mammalian cellular defence mechanism against tumour production is identified in a report in the 02 Dec 2004 issue of Nature (Vol. 432, No. 7017, pp. 639-645). The gene involved, Seladin-1, is somewhat of a surprise package, as it has previously been linked to Alzheimer's disease and cholesterol metabolism.

Expression of oncogenes can lead to the generation of cancer cells; faced with this threat, a cellular senescence (cell ageing) programme kicks in, which is thought to be a weapon in the fight against tumorigenesis. By carrying out a genetic screen, Konstantin Galaktionov and colleagues found that Seladin-1 mediates senescence induced by the protein Ras. Knocking out Seladin-1 side-stepped Ras-induced senescence in rat and human fibroblast cells, allowing the cells to become cancerous as a result of unregulated Ras activity. An interaction between Seladin-1 and the tumour suppressor p53, initiated by oncogenic and oxidative stress, lies at the heart of this regulatory effect of Seladin-1.

CONTACT:

Konstantin Galaktionov (Baylor College of Medicine, Houston, TX, USA)
Tel: +1 713 798 8280, E-mail: kgalakt@bcm.tmc.edu

(C) Nature press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2018 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.