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Cutting Cholesterol With RNAi

 
  November, 23 2004 8:33
your information resource in human molecular genetics
 
     
A technique called 'RNA interference' (RNAi) holds tremendous promise as a means to cure ailments by shutting off disease-causing genes; however, it has been difficult to make the technique work in the cells that need it most. In the 11 Nov 2004 issue of Nature (Vol. 432, No. 7014, pp. 173-178), Hans-Peter Vornlocher and colleagues report a simple and ground-breaking new way to use RNAi to cut cholesterol levels in mice. The technique reveals a practical way in which RNAi might be used to treat a broad range of ailments - including coronary artery disease - that affect an animal's body.

The new work shows how RNAi could be used to treat a much broader range of diseases than is currently possible. "It remains to be seen whether [this] approach can be used to silence other disease-related genes in animal models. If so, it should revolutionise the use of RNAi", writes John Rossi in an accompanying News & Views article.

INFORMATION AND CONTACT

Hans-Peter Vornlocher (Alnylam Pharmaceuticals, Kulmbach, Germany)
E-mail: hpvornlocher@alnylam.de

John Rossi (Beckman Research Institute of the City of Hope, Duarte, CA, USA)
Tel: +1 626 301 8360, E-mail: jrossi@coh.org

(C) Nature press release.


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