home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Promising Early Insight Into HIV Vaccine Research

 
  December, 7 2004 9:02
your information resource in human molecular genetics
 
     
A preliminary investigation of a therapeutic vaccine for HIV has shown some promising signs of efficacy in a subset of the treated patients (see Nature Medicine).

Jean-Marie Andrieu and colleagues from the Centre Biomedical des Saints-Peres, Paris, injected 18 infected Brazilian patients with a vaccine consisting of some of the patients' own immune cells-dendritic cells-loaded with inactivated HIV. The amount of virus in the patients' blood had been stable over the six months prior to vaccination, but after injection of the vaccine, the viral loads began to decline. Eight of the patients maintained low levels of virus for up to a year after the vaccination. The vaccine also boosted the anti-HIV immune response. Importantly, the authors were able to identify particular components of the immune response that correlated with the declining viral load.

Because the study did not contain a control arm, it is unclear which vaccine components were responsible for the decline. But the small-scale study provides some important information about the characteristics of an immune response associated with controlling the HIV infection, which might help scientists evaluate other HIV vaccines. The study also suggests that vaccines based on dendritic cells could be a promising means of treating HIV infection, but the observations need to be confirmed in a larger randomized study.

Author contact:

Jean-Marie Andrieu (Centre Biomédical des Saints-Pères, Paris, France)
Tel: +1 33 1 4260 1922, E-mail: jean-marie.andrieu@biomedicale.univ-paris5.fr

Also published online.

(C) Nature Medicine press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2016 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.